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Figure 2 4 Cancer-promoting cellular behavior induced by mitochondria 4.1 Intermediate metabolites in the TCA cycle modulate the host gene expression profile 4.1.1 Antagonists for epigenetic modification enzymes Recent studies have shown that intermediate metabolites in the TCA cycle, such as succinate, fumarate, and 2-HG, can alter gene expression profiles
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It is important to emphasize the distinction between promising rodent studies and clinical relevance in humans
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