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These flavonoids exert their inhibitory potential by stabilizing key hydrogen bond interactions within the catalytic pocket, suggesting their promise as natural lead molecules for antidiabetic drug development
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Two phase 1b/2 studies showed that an AZA + EPR combination induced ORR in 62–73% patients, CR in 47–50% patients, and cytogenetic response (defined as a TP53 VAF of 83% of patients have increased sEPO levels, ranging from 26–4530 IU/L [167]
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