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The review also provides a critical analysis of epigenetic and transgenerational modifications, mitochondrial oxidative stress, molecular mechanisms of arsenic-induced oxidative stress, and neuronal dysfunction

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A phase I clinical trial sponsored by Imago BioSciences to evaluate the safety, steady-state pharmacokinetics, and pharmacodynamics of IMG-7289 alone or in combination with ATRA in the treatment of AML and MDS patients has been completed (ClinicalTrials.gov Identifier: NCT02842827)