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A frequently cited 2011 study in the Journal of Applied Physiology examined tendon cells taken from rat Achilles tendons and reported that BPC-157 accelerated the outgrowth and migration of those cells and improved their survival under oxidative (hydrogen-peroxide) stress, tracing the effect to the FAK–paxillin signaling pathway
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Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption
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